diff --git a/Models/PlcConfiguration.cs b/Models/PlcConfiguration.cs
index 74d3e0f..48debee 100644
--- a/Models/PlcConfiguration.cs
+++ b/Models/PlcConfiguration.cs
@@ -43,8 +43,10 @@
         public ushort DissolutionStartCoil { get; set; }
         public ushort Dissolution1StartCoil { get; set; }
         public ushort Dissolution1StopCoil { get; set; }
+        public ushort Dissolution1SampleAckCoil { get; set; }
         public ushort Dissolution2StartCoil { get; set; }
         public ushort Dissolution2StopCoil { get; set; }
+        public ushort Dissolution2SampleAckCoil { get; set; }
         public ushort Dissolution1Time { get; set; }
         public ushort Dissolution2Time { get; set; }
     }
diff --git a/ViewModels/StationViewModel.cs b/ViewModels/StationViewModel.cs
index 419503f..31feb70 100644
--- a/ViewModels/StationViewModel.cs
+++ b/ViewModels/StationViewModel.cs
@@ -8,6 +8,8 @@ using System.Collections.Generic;
 using System.Linq;
 using System.Threading.Tasks;
 using System.Windows;
+using System.Windows.Controls;
+using System.Windows.Media;
 using System.Windows.Threading;
 using TabletTester2025.Models;
 using TabletTester2025.Services;
@@ -35,6 +37,10 @@ namespace TabletTester2025.ViewModels
         private DateTime _dissolution2StartTime = DateTime.MinValue;
         private bool _isDissolution1Running;
         private bool _isDissolution2Running;
+        private bool _dissolution1SampleRequestActive;
+        private bool _dissolution2SampleRequestActive;
+        private bool _isDissolution1SamplePromptOpen;
+        private bool _isDissolution2SamplePromptOpen;
         private string _dissolutionResultChannel = "";
         private double _dissolutionResultRate30Min;
         private double _dissolutionResultRSquared;
@@ -309,10 +315,16 @@ namespace TabletTester2025.ViewModels
                 DisintegrationTemp = await _plc.ReadFloatAsync(_plcConfig.DisintegrationTemp);
 
             if (_isDissolution1Running)
+            {
+                await CheckDissolutionSampleAsync(1);
                 updated |= await ReadDissolutionChannelAsync(1);
+            }
 
             if (_isDissolution2Running)
+            {
+                await CheckDissolutionSampleAsync(2);
                 updated |= await ReadDissolutionChannelAsync(2);
+            }
 
             UpdateDissolutionClock();
 
@@ -320,6 +332,129 @@ namespace TabletTester2025.ViewModels
                 DissolutionPlotModel.InvalidatePlot(true);
         }
 
+        private async Task CheckDissolutionSampleAsync(int channel)
+        {
+            ushort coilAddress = channel == 1
+                ? _plcConfig.Dissolution1SampleAckCoil
+                : _plcConfig.Dissolution2SampleAckCoil;
+
+            if (coilAddress == 0)
+            {
+                DissolutionCurveStatus = $"溶出{channel}取样确认线圈未配置";
+                return;
+            }
+
+            bool sampleConfirmed = await _plc.ReadCoilAsync(coilAddress);
+            if (sampleConfirmed)
+            {
+                SetDissolutionSampleRequestActive(channel, false);
+                return;
+            }
+
+            if (IsDissolutionSampleRequestActive(channel) || IsDissolutionSamplePromptOpen(channel))
+                return;
+
+            SetDissolutionSampleRequestActive(channel, true);
+            SetDissolutionSamplePromptOpen(channel, true);
+
+            try
+            {
+                await ShowDissolutionSampleDialogAsync(channel);
+                await _plc.WriteCoilAsync(coilAddress, true);
+                LocalAlarm = $"溶出{channel}已确认取样";
+                DissolutionCurveStatus = "";
+            }
+            catch (Exception ex)
+            {
+                SetDissolutionSampleRequestActive(channel, false);
+                await App.Current.Dispatcher.InvokeAsync(() =>
+                    MessageBox.Show($"溶出{channel}取样确认失败：{ex.Message}", "取样确认失败", MessageBoxButton.OK, MessageBoxImage.Error));
+            }
+            finally
+            {
+                SetDissolutionSamplePromptOpen(channel, false);
+            }
+        }
+
+        private bool IsDissolutionSampleRequestActive(int channel)
+        {
+            return channel == 1 ? _dissolution1SampleRequestActive : _dissolution2SampleRequestActive;
+        }
+
+        private void SetDissolutionSampleRequestActive(int channel, bool value)
+        {
+            if (channel == 1)
+                _dissolution1SampleRequestActive = value;
+            else
+                _dissolution2SampleRequestActive = value;
+        }
+
+        private bool IsDissolutionSamplePromptOpen(int channel)
+        {
+            return channel == 1 ? _isDissolution1SamplePromptOpen : _isDissolution2SamplePromptOpen;
+        }
+
+        private void SetDissolutionSamplePromptOpen(int channel, bool value)
+        {
+            if (channel == 1)
+                _isDissolution1SamplePromptOpen = value;
+            else
+                _isDissolution2SamplePromptOpen = value;
+        }
+
+        private async Task ShowDissolutionSampleDialogAsync(int channel)
+        {
+            bool confirmed = await App.Current.Dispatcher.InvokeAsync(() =>
+            {
+                var dialog = new Window
+                {
+                    Title = $"溶出{channel}取样",
+                    Width = 420,
+                    SizeToContent = SizeToContent.Height,
+                    WindowStartupLocation = WindowStartupLocation.CenterOwner,
+                    ResizeMode = ResizeMode.NoResize,
+                    Background = Brushes.White,
+                    Owner = Application.Current.MainWindow
+                };
+
+                var panel = new StackPanel { Margin = new Thickness(24) };
+                panel.Children.Add(new TextBlock
+                {
+                    Text = "请取样分析后，取样结束后点击“确定已取样”继续运行。",
+                    FontSize = 16,
+                    Foreground = new SolidColorBrush(Color.FromRgb(16, 42, 67)),
+                    TextWrapping = TextWrapping.Wrap,
+                    Margin = new Thickness(0, 0, 0, 18)
+                });
+
+                var button = new Button
+                {
+                    Content = "确定已取样",
+                    Width = 128,
+                    Height = 38,
+                    HorizontalAlignment = System.Windows.HorizontalAlignment.Right,
+                    Background = new SolidColorBrush(Color.FromRgb(21, 101, 169)),
+                    Foreground = Brushes.White,
+                    BorderThickness = new Thickness(0),
+                    FontSize = 15,
+                    FontWeight = System.Windows.FontWeights.SemiBold,
+                    Cursor = System.Windows.Input.Cursors.Hand
+                };
+                button.Click += (_, _) =>
+                {
+                    dialog.DialogResult = true;
+                    dialog.Close();
+                };
+
+                panel.Children.Add(button);
+                dialog.Content = panel;
+                return dialog.ShowDialog() == true;
+            });
+
+            if (!confirmed)
+                throw new InvalidOperationException("取样确认窗口已关闭，未写入确认线圈");
+        }
+
         private async Task<bool> ReadDissolutionChannelAsync(int channel)
         {
             ushort registerAddress = channel == 1
@@ -775,6 +910,7 @@ namespace TabletTester2025.ViewModels
             Phase = TestPhase.Running;
             DissolutionPass = false;
             ResetDissolutionChannel(1);
+            ResetDissolutionSampleState(1);
             _dissolution1StartTime = DateTime.Now;
             _isDissolution1Running = true;
             DissolutionPlotModel.Title = "溶出曲线";
@@ -792,6 +928,7 @@ namespace TabletTester2025.ViewModels
             finally
             {
                 _isDissolution1Running = false;
+                ResetDissolutionSampleState(1);
                 Phase = _isDissolution2Running ? TestPhase.Running : TestPhase.Idle;
                 UpdateDissolutionClock();
             }
@@ -810,6 +947,7 @@ namespace TabletTester2025.ViewModels
             Phase = TestPhase.Running;
             DissolutionPass = false;
             ResetDissolutionChannel(2);
+            ResetDissolutionSampleState(2);
             _dissolution2StartTime = DateTime.Now;
             _isDissolution2Running = true;
             DissolutionPlotModel.Title = "溶出曲线";
@@ -827,6 +965,7 @@ namespace TabletTester2025.ViewModels
             finally
             {
                 _isDissolution2Running = false;
+                ResetDissolutionSampleState(2);
                 Phase = _isDissolution1Running ? TestPhase.Running : TestPhase.Idle;
                 UpdateDissolutionClock();
             }
@@ -857,6 +996,12 @@ namespace TabletTester2025.ViewModels
             DissolutionPlotModel.InvalidatePlot(true);
         }
 
+        private void ResetDissolutionSampleState(int channel)
+        {
+            SetDissolutionSampleRequestActive(channel, false);
+            SetDissolutionSamplePromptOpen(channel, false);
+        }
+
         private async Task FinalizeDissolutionChannelAsync(int channel)
         {
             var times = channel == 1 ? _dissolution1Times : _dissolution2Times;
diff --git a/appsettings.json b/appsettings.json
index 5e35ffe..89af335 100644
--- a/appsettings.json
+++ b/appsettings.json
@@ -37,8 +37,10 @@
     "DissolutionStartCoil": 40,
     "Dissolution1StartCoil": 40,
     "Dissolution1StopCoil": 43,
+    "Dissolution1SampleAckCoil": 44,
     "Dissolution2StartCoil": 30,
     "Dissolution2StopCoil": 33,
+    "Dissolution2SampleAckCoil": 34,
     "Dissolution1Time": 430,
     "Dissolution2Time": 440
   },