diff --git a/Cardiopulmonarybypasssystems/MainWindow.xaml b/Cardiopulmonarybypasssystems/MainWindow.xaml
index 9e7c13b..c67825c 100644
--- a/Cardiopulmonarybypasssystems/MainWindow.xaml
+++ b/Cardiopulmonarybypasssystems/MainWindow.xaml
@@ -1342,6 +1342,24 @@
                                                 </ItemsPanelTemplate>
                                             </ItemsControl.ItemsPanel>
                                         </ItemsControl>
+                                        <Button MinWidth="132"
+                                                Height="34"
+                                                Margin="0,0,10,10"
+                                                Padding="12,4"
+                                                Command="{Binding CalibrateProximalPressureCommand}"
+                                                Content="近端压力校准"
+                                                Background="#FFB7791F"
+                                                IsEnabled="{Binding CanModifySession}"
+                                                ToolTip="M1300" />
+                                        <Button MinWidth="132"
+                                                Height="34"
+                                                Margin="0,0,10,10"
+                                                Padding="12,4"
+                                                Command="{Binding CalibrateDistalPressureCommand}"
+                                                Content="远端压力校准"
+                                                Background="#FFB7791F"
+                                                IsEnabled="{Binding CanModifySession}"
+                                                ToolTip="M1301" />
                                     </WrapPanel>
                                 </Grid>
                             </Border>
diff --git a/Cardiopulmonarybypasssystems/Services/IModbusTelemetryService.cs b/Cardiopulmonarybypasssystems/Services/IModbusTelemetryService.cs
index daa5615..1675742 100644
--- a/Cardiopulmonarybypasssystems/Services/IModbusTelemetryService.cs
+++ b/Cardiopulmonarybypasssystems/Services/IModbusTelemetryService.cs
@@ -16,6 +16,7 @@ public interface IModbusTelemetryService
     float? ReadHoldingFloatRegister(ushort address);
     bool WriteHoldingRegister(ushort address, ushort value);
     bool WriteHoldingFloatRegister(ushort address, float value);
+    bool WriteCoil(ushort address, bool value, string operationName);
     // Legacy PLC coil path retained only for non-RS485 pump compatibility.
     void SetPumpRunning(string pumpKey, bool isRunning);
     void SetValveOpen(string valveKey, bool isOpen);
diff --git a/Cardiopulmonarybypasssystems/Services/ModbusTelemetryService.cs b/Cardiopulmonarybypasssystems/Services/ModbusTelemetryService.cs
index 2e6684f..d402598 100644
--- a/Cardiopulmonarybypasssystems/Services/ModbusTelemetryService.cs
+++ b/Cardiopulmonarybypasssystems/Services/ModbusTelemetryService.cs
@@ -386,6 +386,45 @@ public sealed class ModbusTelemetryService : IModbusTelemetryService, IDisposabl
         }
     }
 
+    public bool WriteCoil(ushort address, bool value, string operationName)
+    {
+        lock (_syncRoot)
+        {
+            if (_master is null)
+            {
+                _lastErrorMessage = $"PLC 离线，未执行{operationName}线圈写入：M{address}";
+                Logger.Warning(
+                    "PLC 离线，跳过线圈写入，Operation={Operation}，Coil=M{CoilAddress}，Value={Value}",
+                    operationName,
+                    address,
+                    value);
+                return false;
+            }
+
+            try
+            {
+                _master.WriteSingleCoil(_slaveId, address, value);
+                Logger.Information(
+                    "PLC 线圈写入成功，Operation={Operation}，Coil=M{CoilAddress}，Value={Value}",
+                    operationName,
+                    address,
+                    value);
+                return true;
+            }
+            catch (Exception ex)
+            {
+                Logger.Error(
+                    ex,
+                    "PLC 线圈写入失败，Operation={Operation}，Coil=M{CoilAddress}，Value={Value}",
+                    operationName,
+                    address,
+                    value);
+                HandleConnectionFailure($"{operationName}线圈 M{address} 写入失败：{ex.Message}");
+                return false;
+            }
+        }
+    }
+
     public void SetValveOpen(string valveKey, bool isOpen)
     {
         lock (_syncRoot)
diff --git a/Cardiopulmonarybypasssystems/ViewModels/MainViewModel.cs b/Cardiopulmonarybypasssystems/ViewModels/MainViewModel.cs
index ef5888f..266dc47 100644
--- a/Cardiopulmonarybypasssystems/ViewModels/MainViewModel.cs
+++ b/Cardiopulmonarybypasssystems/ViewModels/MainViewModel.cs
@@ -31,6 +31,9 @@ public partial class MainViewModel : ObservableObject, IDisposable
     private const string SettingsDirectoryName = "Cardiopulmonarybypasssystems";
     private const string LimitSettingsFileName = "manufacturer-limits.json";
     private const float EngineeringFloatVerificationTolerance = 0.0001f;
+    private const ushort ProximalPressureCalibrationCoil = 1300;
+    private const ushort DistalPressureCalibrationCoil = 1301;
+    private static readonly TimeSpan PressureCalibrationPulseDuration = TimeSpan.FromMilliseconds(300);
     private static readonly (string Name, ushort Address)[] FlowCoefficientRegisters =
     [
         ("流量系数1", 1006),
@@ -62,6 +65,7 @@ public partial class MainViewModel : ObservableObject, IDisposable
     private string _lastTelemetryRefreshFailureMessage = string.Empty;
     private double? _proximalPressureRawKpa;
     private double? _distalPressureRawKpa;
+    private bool _pressureCalibrationPulseInProgress;
     private static string ResolveLimitSettingsPath()
     {
         return Path.Combine(
@@ -875,6 +879,71 @@ public partial class MainViewModel : ObservableObject, IDisposable
         _ = RefreshTelemetryAsync();
     }
 
+    [RelayCommand]
+    private async Task CalibrateProximalPressure()
+    {
+        await PulsePressureCalibrationAsync("近端压力校准", ProximalPressureCalibrationCoil);
+    }
+
+    [RelayCommand]
+    private async Task CalibrateDistalPressure()
+    {
+        await PulsePressureCalibrationAsync("远端压力校准", DistalPressureCalibrationCoil);
+    }
+
+    private async Task PulsePressureCalibrationAsync(string calibrationName, ushort coilAddress)
+    {
+        if (!EnsureSessionEditable(calibrationName))
+        {
+            return;
+        }
+
+        if (_pressureCalibrationPulseInProgress)
+        {
+            LatestAction = "压力校准指令正在执行，请稍后再操作。";
+            return;
+        }
+
+        _pressureCalibrationPulseInProgress = true;
+        try
+        {
+            Logger.Information(
+                "执行压力校准脉冲，CalibrationName={CalibrationName}，Coil=M{CoilAddress}，TelemetryOnline={TelemetryOnline}",
+                calibrationName,
+                coilAddress,
+                IsTelemetryOnline);
+
+            if (!_telemetryService.WriteCoil(coilAddress, true, calibrationName))
+            {
+                LatestAction = IsTelemetryOnline
+                    ? $"{calibrationName} 指令下发失败：{_telemetryService.LastErrorMessage}"
+                    : $"{calibrationName} 指令未下发，PLC 当前离线。";
+                TraceEvents.Insert(0, NewTrace("压力校准", $"{calibrationName} / M{coilAddress}=1 下发失败"));
+                return;
+            }
+
+            LatestAction = $"{calibrationName} 已触发，M{coilAddress}=1。";
+            TraceEvents.Insert(0, NewTrace("压力校准", $"{calibrationName} / M{coilAddress}=1"));
+
+            await Task.Delay(PressureCalibrationPulseDuration);
+
+            if (!_telemetryService.WriteCoil(coilAddress, false, calibrationName))
+            {
+                LatestAction = $"{calibrationName} 释放失败，请检查 PLC 线圈 M{coilAddress}。";
+                TraceEvents.Insert(0, NewTrace("压力校准", $"{calibrationName} / M{coilAddress}=0 释放失败"));
+                return;
+            }
+
+            LatestAction = $"{calibrationName} 已完成校准脉冲。";
+            TraceEvents.Insert(0, NewTrace("压力校准", $"{calibrationName} / M{coilAddress}=0"));
+        }
+        finally
+        {
+            _pressureCalibrationPulseInProgress = false;
+            _ = RefreshTelemetryAsync();
+        }
+    }
+
     [RelayCommand]
     private void ClearTrendData()
     {